Rather than using the command line to set up the options you want to use in Mame you can adjust the file C:\Mame\mame.ini. This is where Mame stores it's default configuration information.

To edit the file in Windows find the mame.ini file in the C:\Mame folder. To open the file you may need to associate it with a text editor. To do this, simply right click it and select the "Open With..." option. Use Notepad if you don't have your own prefered editor. You can now double click the mame.ini file and it will open.

Here is an example of a mame.ini file...

If you look at the file, the options are grouped together under headings. The format of the options are fairly simple to follow. Most things with a yes / no answer are denoted by 0 for no and 1 for yes. there are also a few numerical options (e.g. gamma) and a few that require a text answer (e.g. rom path)

If you configure this file correctly you can significantly reduce the amount of options on the command line.

Also, don't worry if you muck the whole file up because you can delete it and run mame64 -cc from the command line to make another.